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Skeletal System

NSAIDs

PA Criteria

Tier 1 products are covered with no authorization necessary.

Tier 2 authorization criteria:

  • Previous use of at least two Tier 1 NSAIDs (from different product lines) plus a PPI within the last 120 days, or
  • For those with prior GI bleed who must have an NSAIDs, a Tier 2 product may be approved (Celebrex should also be taken with a PPI).

Special PA approval criteria:

  • Special indications, such as the diagnosis of gout for indomethacin, or
  • Previous use of at least two Tier 1 NSAID (from different product lines) and reason why a special formulation is needed over a Tier 1 product.

NOTE: In order for previously utilized Tier 1 medications to count as trials toward a Tier 2 authorization, the member's NSAID therapy must have been continuous. Dates and dosing information for Tier 1 trials must be included on petition  for authorization. Trials with OTC formulations of Tier 1 products must be dosed at full prescription strength.

Tier 1
Tier 2
Tier 3
  • naproxen sodium (Anaprox®)
  • flurbiprofen (Ansaid®)
  • diclofenac potassium (Cataflam®)
  • sulindac (Clinoril®)
  • oxaprozin (Daypro®)
  • etodolac (Lodine®)
  • etodolac ER (Lodine XL®)
  • meclofenamate (Meclomen®)
  • meloxicam (Mobic®)
  • ibuprofen (Motrin®)
  • naproxen (Naprosyn®)
  • naproxen EC (Naprosyn EC®)
  • ketoprofen (Orudis®)
  • ketoprofen ER (Oruvail®)
  • nabumetone (Relafen®)
  • tolmetin (Tolectin®)
  • diclofenac ER (Voltaren XR®)
  • diclofenac sodium (Voltaren®)
  • diclofenac sodium/misoprostol (Arthrotec®)
  • celecoxib (Celebrex®)
  • fenoprofen (Nalfon®)
  • ibuprofen/famotidine (Duexis®)
  • piroxicam (Feldene®)
  • diclofenac epolamine (Flector®)
  • indomethacin (Indocin®)
  • naproxen sodium (Naprelan®)
  • diclofenac sodium drops (Pennsaid®)
  • mefanamic acid (Ponstel®)
  • esomeprazole/naproxen (Vimovo®)
  • diclofenac sodium gel (Voltaren Gel®)
  • diclofenac potassium (Zipsor®, Cambia®)
  • Ketoprofen 200mg xr 24hr
  • diclofenac submicronized (Zorvolex®)
Gout
colchicine (Colcrys®)

PA criteria:

A supply of 6 tablets per 2 days every 365 days will not require a petition. Long term use will require a petition and member must have:

  • Failure of allopurinol defined by persistent gouty attacks with serum urate levels below 6.5mg/dL.
  • Clinical reason why colchicine/probenecid would not be a viable option for the member.
  • Quantity limit of #60 per 30 days will apply for gout.
febuxostat (Uloric®)

PA Criteria:

  • Failure of allopurinol defined by persistent gouty attacks with serum urate levels below 6.5mg/dL.
  • Clinical reason why allopurinol is not a viable option for the member.
  • Quantity limit of #30 per 30 days will apply.
Skeletal Muscle Relaxants

PA Criteria:

Tier 1 products are covered with no authorization necessary.

Tier 2 authorization requires:

  • Documented trial of two Tier 1 medications within the last 90 days with no beneficial response after a minimum of 2 weeks of continuous therapy during which time the medication has been titrated to the recommended dose.
Tier 1
Tier 2
Special PA
  • cyclobenzaprine (Flexeril®)
  • baclofen (Lioresal®)
  • orphenadrine (Norflex®)
  • chlorzoxazone (Parafon Forte, Paraflex®)
  • methocarbamol (Robaxin®)
  • tizanidine (Zanaflex®)
  • metaxolone (Skelaxin®)
  • carisoprodol 350mg w/aspirin
  • carisoprodol 350mg, ASA, codeine
  • cyclobenzaprine ER (Amrix®) Caps
  • cyclobenzaprine 7.5mg (Fexmid®) Tabs
  • carisoprodol (Soma®) 250mg, 350mg
  • tizanidine (Zanaflex®) Caps
Soma

PA Criteria:

A cumulative 90 therapy day window per 365 days will be in place for these products, further approval will be based on the following:

  • An additional approval for 1 month will be granted to allow titration or change to a Tier 1 muscle relaxant. Further authorizations will not be granted.
  • Clinical exceptions may be made for members with the following diagnosis and approvals will be granted for the duration of one year:
    • Multiple Sclerosis
    • Cerebral Palsy
    • Muscular Dystrophy
    • Paralysis
  • A quantity limit of 120 per 30 days will also apply for the carisoprodol and carisoprodol combination products.

Soma 250

Approval for coverage is based on the following criteria:

  • Documentation regarding member's inability to use other skeletal muscle relaxants including carisoprodol 350 mg, and specific reason member cannot be drowsy for even a short time period. Member must not have other sedating medications in current claims history.
  • A diagnosis of acute musculoskeletal pain, in which case, the approval will be for 14 days per 365 day period.  Conditions requiring chronic use will not be approved.
Amrix and Fexmid

PA criteria:

  • Approval requires FDA approved indication and clinical documentation of inability to take other generically available forms of cyclobenzaprine hydrochloride.
  • A quantity limit of 30 capsules for 30 days placed on Amrix.
  • A quantity limited of 90 tablets for 30 days placed on Fexmid.
Zanaflex

PA Criteria:

  • Trizanidine tablets must be tried prior to consideration of the capsules. The capsules maybe considered for approval if there is supporting information as to why the member cannot take the tablets
Osteoporosis
Tier 1
Tier 2
Special Criteria Apply
  • alendronate (Fosamax®)
  • calcium + vitamin D
  • alendronate +D (Fosamax +D®)
  • lbandronate (Boniva®)
  • risedronate (Actonel®)
  • risedronate delayed release (Atelvia®)
  • alendronate (BinostoTM )
  • ibandronate (BonivaTM )
  • teriparatide (Forteo®)
  • denosumab (Prolia®)
  • zoledronic acid (Reclast®)
Bisphosphonate

PA Criteria:

Tier 1 products are available with no authorization necessary.

  • Calcitonin and raloxifene are not included as Tier-1 trials.
  • Must be used at recommended doses in conjunction with Tier-1 bisphosphonate for trial to be accepted unless member has a recent laboratory result showing adequate Vitamin D or member is unable to tolerate calcium. OTC Calcium and Vitamin D are only covered  for members with osteoporosis.

Criteria for Moving to Higher Tiers

  • Treatment failure with all lower tiered products, or
  • Contraindication to all lower tiered products, or
  • Allergic reaction to all lowered tiered products, or
  • Specific indication not covered by a lower tiered product.
  • No concomitant use of bisphosphonate therapy will be approved. No additional bisphosphonate therapy may be approved for 365 days following zoledronic acid infusion.
  • Clinical Exceptions/Additional Criteria: 
    • Risedronate may be approved for members with high risk for gastric side effects.
    • Zoledronic acid may be approved for members with a diagnosis of Paget’s disease or for osteoporosis if secondary diagnosis meets criteria below:
      • Severe esophageal disease (e.g., ulcerations, strictures)
      • Inability to take anything by mouth
      • Inability to sit or stand for prolonged periods
      • Inability to take an oral bisphosphonate for other special medical circumstances that justify the method of administration

Forteo Criteria:

  • Teriparatide requires a BMD test (T-score at or below 2.5) within the last month, and a minimum 12 month trial with a bisphosphonate plus adequate calcium and vitamin D, and a 12 month trial of Prolia (Denosumab), unless contraindicated, intolerant, or  allergic, that did not yield adequate results.

Quantity Limits apply bases on FDA maximum doses.  

denosumab (Xgeva®)

Consideration for approval will be based on the following criteria:

  • An FDA approved indication of prevention of skeletal-related events in patients with bone metastases from solid tumors OR treatment of adults and skeletally mature adolescents with giant cell tumor of the bone (GCTB) that is unresectable or where surgical  resection is likely to result in severe morbidity.   
Prolia™, Reclast® , Boniva® , IV requires

Prior Authorization Criteria:

  • A minimum 12 month trial with a Tier 1 or Tier 2 bisphosphonate plus adequate calcium and vitamin D, or
  • Contraindication to or intolerable adverse effects with Tier 1 and Tier 2 products.
  • Clinical exceptions may apply for members with:
    • Severe esophageal disease (e.g., ulcerations, strictures)
    • Inability to take anything by mouth
    • Inability to sit or stand for prolonged periods
    • Inability to take bisphosphonates orally for other special medical circumstances that justify the method of administration
Last Modified on Jul 16, 2021
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